TUCSON, Ariz. -- That two-quarterback system is working just fine for the Oregon Ducks, and life keeps getting tougher for the Arizona Wildcats and their embattled coach John Mackovic.
Demetrius Williams caught three touchdown passes -- two from Kellen Clemens and one from Jason Fife -- as Oregon handed Arizona its 12th consecutive Pac-10 home loss, 48-10 on Saturday night.
Fife threw for another score and ran for one, and the Ducks' defense shut down the Wildcats, who have been outscored 107-23 in consecutive home losses to LSU and Oregon.
"Those two have done a great job of complementing each other," Ducks coach Mike Bellotti said, "and of continuing to run the offense in a variety of ways."
Clemens completed 11 of 17 passes for 168 yards, Fife 11-of-15 for 115 yards. Neither was intercepted.
"It just works," Clemens said. "Jason and I trust the coaches to make their decision as to who's going to go in and who isn't, and as long as the team's rollin' we're happy with it."
Only a 53-yard touchdown pass from Ryan O'Hara to Biren Ealy with 3:42 to play prevented it from being the fourth-worst home loss in Arizona football history. Last week's 59-13 beating by LSU was the third-worst.
"As a total picture, it just wasn't anything close to what we had hoped for," Mackovic said. "It is tough when you lose two game like that. Everyone is searching for answers."
The Ducks (3-0, 1-0 Pac-10)) beat Arizona (1-2, 0-1) for the fifth time in a row, the last three in Tucson. Oregon has won nine of 10 against the Wildcats.
Mackovic fell to 0-8 in home Pac-10 games and 3-14 in conference games overall in just over two seasons with the Wildcats.
Fans in the student section chanted "Fire Mackovic!" early in the game.
Williams, a sophomore who became Oregon's prime receiver after Samie Parker left with a sprained ankle in the first quarter, had five catches for 139 yards, including touchdowns of 3, 65 and 30.
"Samie went down and I just knew I had to step it up," Williams said. "The whole wideout group, we just came together.
The Ducks, who host No. 5 Michigan next weekend, led 20-0 and dominated the first-half statistics 210 yards to 42, 108-2 on the ground. Oregon led in time of possession through the first two quarters 33:48 to 11:12.
Oregon took a 3-0 lead on Jared Siegel's 29-yard field goal with 9:42 left in the first quarter after Kevin Mitchell recovered a fumble by Arizona's Mike Bell at the Wildcats 19.
Fife replaced the starter Clemens and directed the Ducks 66 yards on 13 plays. The drive stalled on the Arizona 7 and Siegel's 22-yard field goal made it 6-0 with 1:24 remaining in the first quarter.
The Ducks used up 5:17 of the second quarter on a 12-play, 51-yard drive, Fife scoring on a five-yard option play. The Oregon senior seemed stopped in the backfield, but he stepped past at least three would-be tacklers for the score to make it 13-0 with 8:56 to go in the first half.
Clemens returned and Oregon went 48 yards in nine plays, using up another 4:03. On third-and-goal from the 3, Clemens threw to Williams for the touchdown to put the Ducks up 20-0 with 1:02 left until halftime.
The Wildcats took the second-half kickoff and drove to the Oregon 27, aided by a third-down facemask penalty. Bobby Gill's 44-yard field goal cut the lead to 20-3.
The Ducks blew it open with touchdowns on their next four possessions, including Clemens' 65-yarder to a wide-open Williams and Fife's 30-yard sidelines pass to the sophomore receiver.
Clemens and Fife combined to complete 13 consecutive passes from late in the second quarter through the third.
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